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Since mitochondrial activities are developmentally regulated in the life cycle of trypanosomatids, Ufm1 mediated modifications of mitochondrial proteins may be important in such regulation.
Redox mediated modifications of protein bound thiols (Cys) are one important modification that regulates the activities of cellular proteins, both in Escherichia coli[ 19], yeast [ 20] and cyanobacteria [ 21].
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The NBS mediated modification of purified enzyme resulted in total loss of activity.
Its detailed molecular mechanisms presumably merge into the GPR signaling mentioned above, G αi signaling- (which is GPR's intracellular downstream signaling-) mediated modification of TRP functions [ 28, 35].
Lipid hydroperoxide-mediated modifications of proteins are receiving increasing attention because of their possible involvement in various degenerative diseases.
However, our data have not revealed whether the inhibition of PhoPQ signaling is a consequence of NO-mediated modifications of the sensor kinase or response regulator or is indirectly related to the interference of RNS with upstream signaling cascades.
Drug-mediated modifications of nuclear FoxO trafficking.
Although knockdown of RUNX2 had no substantial effect on ADR-mediated modifications of p53, RT-PCR analysis revealed that ADR-mediated induction of p53-target genes is further enhanced in RUNX2 knockdown cells.
While this eastward trend may owe to chance, it could also be due to human-mediated modifications of shallow coastal habitats occurring earlier in the west, or limiting conditions in the east [ 25] that populations have adapted or acclimated to overtime [ 63].
In our previous studies, we showed that C60 derivatives such as polyhydroxylated C60 derivatives regulate Nrf2 activation possibly by ROS-mediated modification of sulfhydryl groups of Keap1 [11].
The authors concluded that the NO-mediated modification of enzymatic activity of Glo1 is possibly the consequence of structural changes that are induced by this modification.
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