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OPN has been shown to amplify Ccl-2 mediated migration of macrophages [19].
These data are compatible with a selective role of this isoform, and indicate that GAGs could be critical in orchestrating the CXCL12 mediated migration of cells, depending on the chemokine isoform and the nature of the GAGs to which it binds, either during development or post-natal life.
WASP has been previously implicated in ROBO4 mediated migration of HEK-293T cells [ 27].
HGF also mediated migration of MSCs to sites of apoptotic cell death and towards HGF-expressing glioblastomas, and this observation has been exploited in gene therapy to deliver therapeutic drugs to the tumor cells [ 85].
Our data indicate that the Ly294002 mediated activation of the spontaneous as well as EGF and SDF-1α mediated migration of M13MDA435-1 hybrid cells was most likely attributed to an active RAF-AKT crosstalk in these cells.
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Gardner, J. A., Ha, J. H., Jayaraman, M. & Dhanasekaran, D. N. The gep proto-oncogene Galpha13 mediates lysophosphatidic acid-mediated migration of pancreatic cancer cells.
Therefore, Syk-Tyr323 as well as Syk-Tyr348 may be required for the spatio-temporal coordination of Vav-mediated and PI3K p110δ-mediated signaling pathways, a prerequisite for efficient β2 integrin-mediated migration of PMN.
Whether Sema3E/PlexinD1 signalling is enhanced in parallel with the recently described contact-mediated migration of CR cells is a question that warrants further study.
Yu, J. et al. SDF-1/CXCR4-mediated migration of transplanted bone marrow stromal cells toward areas of heart myocardial infarction through activation of PI3K/Akt.
In this sense, we cannot also rule out the possibility that haemophilic interactions between PlexinD1 expressed by CR14 may play a role in contact-mediated migration of CR cells, as happens with members of the plexin B subfamily (Plexin B3 68.
These data suggest that CXCL12-mediated migration of ESNPs requires the function of CXCR4.
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