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Our study suggests a pivotal role of Th1/Tc1 differentiated T-cells in immune-mediated marrow destruction of AA patients.
Examples of increased PG degradation include the FGF2-stimulated, MMP-13-mediated or ADAMTS4-mediated and ADAMTS5-mediated destruction of aggrecan.
Although the exact pathogenic mechanism is still unknown, beside a primary stem cell defect [ 2] and a disturbed microenvironment [ 3], pre-/clinical data suggest an immune-mediated destruction of marrow progenitor/stem cells [ 1, 4].
Other authors have also observed lymphopenia in patients with hepatitis-virus-associated aplastic anaemia (HAA), suggesting that HAA may be influenced by the immune-mediated destruction of bone marrow [ 58].
RNase H+ mediated destruction of template RNA can prevent this problem and improve the sensitivity of qPCR analysis.
Details about the Auxin mediated destruction of AID tagged proteins in yeast was previously described (Eng et al., 2014).
Zaldumbide, A. et al. Genetically engineered human islets protected from CD8-mediated autoimmune destruction in vivo.
Rosenberg, A. S. & Singer, A. Cellular basis of skin allograft rejection: an in vivo model of immune-mediated tissue destruction.
These data demonstrated that the VHL-mediated protein destruction motif of HIF-1α endowed procaspase-3 with hypoxia-specific cytotoxicity.
This may represent a form of nonimmune-mediated platelet destruction in ponies acutely infected with EIAV.
Escape from immune-mediated tumor destruction has been recognized as a hallmark of cancer [47].
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