Sentence examples for mediated loss of from inspiring English sources

Moreover, SphK-1 overexpression replenished DHS mediated loss of NO in macrophages (Fig. 4C).

One recent publication showed that EMT mediated loss of contact inhibition in hepatocarcinoma cells, and reexpression of E-cadherin restored cell-cell contacts [58].

Exposure of cells to estrogen upregulated Grx1 and prevented L-BOAA mediated loss of MMP clearly delineating the important role of Grx1 in maintaining mitochondrial function and thereby the cell viability.

However, the effects of Rab5DN and Rab11DN have been shown to reflect RNAi mediated loss of function, which suggests that the DN proteins specifically blocks Rab function [40], [41], [42].

Whether the recently reported regulated intramembrane proteolysis (RIP) mediated loss of EpCAM from the tumor cell surface might be one of the reasons for the limited efficacy of EpCAM-based cancer therapies remains to be established [24].

This was associated with an IL-1 mediated loss of endothelium-dependent relaxation and an increase in vessel wall Nox 4. Inhibition of IL-1 restored endothelium-dependent vasodilatation and reduced levels of arterial oxidative stress.

A DUB RNAi library mediated loss-of-function screen also identified USP15 as a key regulator of TGF-β signaling (Eichhorn et al., 2012).

Together, the results of these complementary genetic and siRNA-mediated loss-of-function experiments point to an important physiologic function of cellular Nab2 in negative modulation of basal and TGF-β-induced collagen gene expression.

By using an RNAi-mediated loss-of-function screening approach, we have identified CSNK1E, a member of the casein kinase family, as an essential regulator of β-catenin activity and proliferation in breast cancer cell lines.

By using RNAi-mediated loss-of-function approach, we observed that HuR regulates the mRNA and in turn the protein levels of caspase-2 in a negative manner.

Short hairpin RNA (shRNA) mediated loss-of-function screens in mammalian cells are powerful tools for the discovery of novel gene functions.