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Furthermore, obese participants showed an increased whole-body beta-adrenergically mediated lipolytic response versus lean participants.
The present study demonstrates in vivo that obese men have a blunted beta-adrenergically mediated lipolytic response in abdominal SAT.
To our knowledge, this is the first study to show in vivo that obese participants have a blunted beta-adrenergically mediated lipolytic response per unit of adipose tissue.
We hypothesised that beta-adrenergically mediated lipolytic response at the whole-body and abdominal subcutaneous adipose tissue (SAT) level is impaired in vivo in obese persons.
We demonstrated in vivo that beta-adrenergically mediated lipolytic response is impaired systematically and in abdominal SAT of obese versus lean men.
There is in vitro evidence for a blunted beta-adrenergically mediated lipolytic response in abdominal subcutaneous adipose tissue (SAT) of obese individuals and evidence for this at the whole-body level in vivo.
Similar(51)
For example, human visceral white adipose tissue exhibits a stronger lipolytic response to catecholamines than subcutaneous adipose tissue, and the anti-lipolytic affect of insulin is stronger in subcutaneous adipose tissue than visceral adipose tissue [38], [39].
In the obese group, however, NA-stimulated lipolytic activity was significantly suppressed (ED50 = 26.5 nM); Boc5 treatment resulted in an evident improvement (ED50 = 13.2 nM), while lipolytic response to NA in pair-fed mice was only minimally recovered (ED50 = 18.6 nM; Figure 3D).
Blunted lipolytic response has been linked to obesity [ 1].
Interestingly, the lipolytic response to resistance exercise was similar to the response to aerobic exercise (4).
The lipolytic response to β2-stimulation β2-stimulationlean than is obese persons [ 38].
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