Sentence examples for mediated kit from inspiring English sources

Our data supported the potential use of AUY922 in treating TKI-refractory, KIT-expressing GIST and highlighted a possible role for autophagy in HSP90AA1 mediated KIT protein degradation.

The PCR product was used as template to synthesize double-stranded of the target gene RNA in vitro using the MEGAscript RNA-mediated interference kit (Ambion).

Since oncogenic c-Kit (V560G) is not fully activated, SCF treatment is able to induce further upregulation of c-Kit mediated signaling [ 25].

The enChIP (engineered DNA-binding molecule-mediated ChIP) assay kit uses an antigen-tagged, enzymatically inactive ("dead") Cas9 protein to map the specificity of the nuclease for genome editing applications via ChIP.

Isolation of full length cDNA for the ovine PITX3 gene was achieved by a rapid amplification of cDNA ends (RACE) protocol with the FirstChoice RNA ligase-mediated (RLM -RACE kit (Applied Biosystems).

Further studies of AKN-028-mediated inhibition of KIT, and of other possible targets, are underway.

The activity of imatinib in GIST is mainly due to its ability to inhibit c-KIT mediated kinases.

It has been shown that STAT5 is required for c-Kit mediated mast cell survival and differentiation [ 23].

Therefore, an enhanced proliferation of mast cells as observed in our patients seems to be unlikely mediated via c-kit inhibition on the mast cells themselves.

In addition, NGF-TrkA activated cytokine genes (p = 3.33E-03) but drastically fewer genes than c-Kit mediated gene modulation (Table 2).

The 5′ RACE adapter, the primers 5′ rapid amplification of cDNA ends (RACE) Outer and 5′ RACE Inner were provided in the First Choice RNA ligase-mediated (RLM -RACE kit (Ambion, Inc., Austin, TX, USA).