Sentence examples for mediated its effects from inspiring English sources

The CPC program's association with reduced school mobility and increased attendance in higher-quality schools also significantly mediated its effects on maltreatment and neglect.

Genetic analyses showed that Ot B mediated its effects by increasing the activity of heat shock transcription factor (HSF) by upregulating the expression of hsf-1 and its target genes, hsp-12.6, hsp-16.2 and hsp-70.

Comparing intracellular (cytosolic) and membranous (surface) receptor pools, we found that chitin-induced TLR4 upregulation was not due to increased translocation from intracellular receptor storage pools (data not shown), suggesting that chitin mediated its effects at the transcriptional level.

Metformin mediated its effects through activation of AMPKThr172 together with inhibition of the IR/IGF-IR signalling pathway.

These results clearly suggested that thiacremonone mediated its effects through modulation of cysteine residues of the p50 subunit of NF-κB.

Additionally, the in vitro results were corroborated in severe combined immunodeficient (SCID) mouse xenograft model of prostate cancer, suggesting that resveratrol mediated its effects through inhibition of Akt/miR-21 signalling pathway [ 63].

However, the mechanisms or whether Wnt5A mediated its effect through CaMKII activation, were not investigated.

Therefore, JMJD6 did not confer unresponsiveness to this growth factor, but probably mediated its effect via repression of gene expression.

An additional challenge with interpreting these findings lies with understanding which component of the intervention programme mediated its effect.

Collectively, these data suggested that IFNB1 mediated its effect on autophagy, at least partly, by inhibiting the MTORC1 pathway.

It is currently unknown how celecoxib mediates its effects on cytokine expression and NF-κB activity.