Sentence examples for mediated internalisation of from inspiring English sources

Treatment with wortmannin, a specific inhibitor of phosphatidylinositide 3-kinase (PI3K), did not block stabilin-1 mediated internalisation of acLDL as well as its trafficking to early endosomes, whereas it induced enlargement of stabilin-1/acLDL positive endosomes as well as partial dissociation of EEA1 from these structures.

Receptor-mediated internalisation of J591Cdia was analysed by confocal microscopy.

Similarly, depolymerisation of actin by cytochalasin D, previously shown to impair phagocytosis of E. coli in S2 cells [11], also inhibited clathrin-mediated internalisation of naked dsRNA (Fig. S2) and could also not distinguish between endocytic and phagocytic uptake.

Hippocampal LTD involves PICK1-mediated internalisation of GluA2-containing AMPARs (Kim et al, 2001; Seidenman et al, 2003; Terashima et al, 2008).

Thus, dominant-negative mutants of dynamin 1 dramatically prevented the α-melanocyte-stimulated hormone-mediated internalisation of the MC4R receptor in HEK 293 cells (Shinyama et al, 2003).

As overexpression of WT-PICK1 reduces surface GluA2, and LTD in CA1 pyramidal neurons involves PICK1-mediated internalisation of GluA2-containing AMPARs, the absence of LTD in WT-PICK1 overexpressing neurons represents an occlusion rather than a block per se.

Hippocampal LTD involves PICK1-mediated internalisation of GluA2-containing AMPARs (Kim et al, 2001; Seidenman et al, 2003; Terashima et al, 2008), but it is unknown whether Arp2/3 regulation by PICK1 is required.

Ephrin type-A receptor 2 effectively mediates internalisation of targeted adenoviral vectors into OS cells.

In a different study, Takahashi et al (2012) studied the consequences of a pilV mutation on TFP-mediated internalisation into endothelial and epithelial cells.

Importantly, in contrast to lipidated (e.g. palmitoylated) peptides, inclusion of the Pam3CSS lipopeptide anchor in the liposomal formulations might also induce Toll-like receptor 2-mediated internalisation by DCs (Hertz et al, 2001).

Furthermore, overexpression of class I PI3K increased bacterial uptake, whereas wortmannin blocked CEACAM1-, CEand and CEACAM6-mediated internalisation.