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Gap junction mediated intercellular communication was assessed with microinjections and FACS analysis of calcein transfer.
This inhibition results from a reduction of the gap junction mediated intercellular communication of these cells (GJIC), from an inhibition of their growth and thymidine incorporation and from a modulation of the apoptotic cascade.
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Inspired by microvesicle-mediated intercellular communication, we propose a hybrid vector for magnetic drug delivery.
These results demonstrate that gene retention is not uniform after WGD in vertebrates, and suggest a Darwinian selection of GPCR-mediated intercellular communication in metazoan organisms.
Significant increases in skin wound healing rates occur by altering GJ-mediated intercellular communication, but the underlying cellular and molecular basis remains unclear (Wright et al. 2009).
The presence of nucleic acids, mRNAs and microRNAs in exosomes, was pointed out in 2007, as a first strong indication of vesicle-mediated intercellular communication.
Thus, exosome-mediated intercellular communication within tumor cells may have a role in efficient luciferase or Raf-1 knockdown within the tumor.
In the present study several structurally related alkyl glycol ethers were examined for their ability to block junction-mediated intercellular communication.
Urothelium has highly developed connexin-mediated intercellular communication (Grossman et al, 1994; Lyng et al, 1996) and this could explain the more pronounced bystander effect observed in the urothelial outgrowth in comparison with fibroblast cultures.
Nonetheless, as exosome-mediated intercellular communication may be dominated by transferred miRNA [ 5], exosomes of different tumors could distinctly affect the immune system, which can be easily evaluated in vitro before vaccinating with tumor-exosomes.
Cell interactions due to gap-junction-mediated intercellular communication have been shown to have crucial roles in the regulation of the glial-cell network and nervous system functions [ 25].
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