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We found that 750 nM NBQX blocked a net inward current of 13.9±8.9 pA and decreased the root mean square membrane current from 10.7±7.9 pA to 2.5±2.7 pA, consistent with the blockade of a sustained AMPA mediated input to the SBAC (Figure 5 A & B; p<0.005, n = 8).
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Interestingly, in the rat, expression is observed in the EPN and intercalated cells, but only scarcely in the LA and BA [33], indicating that a common feature of NPS function in these species may be related to the modulation of EPN-mediated input to the LA/BA and its output towards the central amygdala.
GABAA-mediated input to PTNs seems to play a rather small role in causing their periods of lowered activity.
The variable μ t is a threshold while α i t represents the adaptation-mediated input to the unit i.
When the animal reaches adulthood, a decrease in phasic inhibitory signalling is observed, due to a selective reduction in glycine receptor (GlyR -mediated input to GlyR -mediatedglutamaterginputmina II neurons and a decreased densito of tonic GABAergicandd current in the glutamatergic populamina (LIIet al., 2013).
DOI: http://dx.doi.org/10.7554/eLife.00467.012 The spectral separation of the photopigments in rods and long-wavelength (L) cones and the considerably higher gain of rod-mediated signals allowed separation of rod- and cone-mediated inputs to a ganglion cell.
On the other hand, a more complex case is found in a cerebellar diffuse white matter injury model in which hypoxia-induced loss of GABA- α receptor-mediated synaptic input to OPCs significantly suppressed OPCs maturation while promoting proliferation [ 79].
The finding that SMT may have a local hypoalgesic effect specific to C-fiber mediated input for asymptomatic subjects adds to the previous literature and provides direction for future study.
This specific timing of transcript accumulation suggests that photoreceptor-mediated input signalling to the clock machinery may be particularly synchronized in tomato.
Orthodromic paired-pulse stimulation was used to assess anesthetic effects on either glutamate-mediated excitatory inputs or GABA-mediated inhibitory inputs to CA1 neurons.
On parasol ganglion cells provide information to cortical circuits about subtle changes in contrast (Kaplan and Shapley, 1982) and receive abundant rod-mediated input at low light levels (Purpura et al., 1988; Field et al., 2009).
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