AUX1, which mediates influx of IAA into cells, was localized asymmetrically in the plasma membrane of certain cell types, facilitating directional auxin transport [ 69].
Although nAChR is an ion channel mediating influx of Na+ and Ca2+ and efflux of K+, its activation by a ligand, such as nicotine, elicits both ionic and non-ionic signaling events regulating phosphorylation and dephosphorylation of target proteins.
At high-dose ara-C (1 3 g m−2), however, hENT1 seems less crucial although plasma concentrations might not exceed the Km of the transporter mediated influx.
Our results do not exclude involvement of other P2XR since it is known that subtype receptors from the P2X family mediate influx of Ca2+ into stimulated cells [ 12].
In line with previous observations, all these results confirmed that the HCN2-mediated influx of Ca2+ triggered caspase-independent, AIF-mediated apoptosis.
Thus, our data support that NMDA receptor-mediated influx of calcium in OGD cultures is responsible for calpain-mediated procaspase-12 proteolysis activation.
Both expression and release of chemokines were inhibited by antagonists for SOC-mediated influx of Ca2+ suggesting ATP induced the activation of a SOC-dependent pathway.
In the presence of the SOC inhibitors, SKF96365 or gadolinium, or with Ca2+-free solution, ATP responses lacked a slow phase suggesting the secondary component was due to SOC-mediated influx of Ca2+.
These results suggest that isolated, unmyelinated axons are vulnerable to hypoxic injury which is mediated by influx of sodium and calcium but is independent of glutamate receptor activation.
OAG-activated current mediated the influx of Ca2+, Ba2+, and Sr2+ into Jurkat and PBLs; on the contrary, in case of SOCE (CRAC) activation cation influx was Ca2+-selective, without measurable Ba2+ component [ 218].
Human copper transporter 1 (hCTR1) is the high-affinity copper influx transporter in mammalian cells that also mediates the influx of cisplatin.
