Sentence examples for mediated independently from inspiring English sources

The results reported here demonstrate a hitherto unknown relationship between the α7-nAChR and the non-enzymatic functions of acetylcholinesterase, mediated independently by its C-terminal domain.

Clearly the mechanism by which PPAR agonists dilate vessels acutely must be mediated independently of gene induction as the response is seen within minutes of adding the drug.

This study addressed whether these various activities of Nef are linked or mediated independently of each other and assessed their relative contribution to the reduction of exogenously triggered TCR signal transmission observed in Nef expressing T lymphocytes.

In this study we show that the dilator effect of GW0742 in pulmonary artery was mediated independently of endothelial nitric oxide, as responses were not prevented by the nitric oxide synthase inhibitor L-NAME.

Clearly with such acute exposure, and as platelets have no nucleus, effects of PPARβ/δ agonists on platelet function must also be mediated independently of gene induction and the nucleus.

One of the more important findings of this work was that PVT1 effects on expression of FN1, COL4A1, and PAI-1 may be mediated independently of TGFB1, a well-known profibrotic factor which promotes tissue fibrosis by upregulating genes encoding ECM proteins in response to hyperglycemia [20].

This autonomy of motion between the 70N and 70AB modules supports a model in which the two binding functions of RPA are mediated fully independently, but remain differentially coordinated depending on the length of their flexible tethers.

This may be mediated either independently of NRP1 by, for example, a direct interaction between NRP2 and PDGFRα or β, and/or could arise from an interaction between NRP1 and NRP2.

Whereas Gal-1 induces PBMC apoptosis via caspase activation [9], [27], Hahn et al. reported, that T cell death induced by Gal-1 in MOLT-4 is mediated caspase-independently [28].

Our results show that both meningococcal variants of the T4P-associated PilC component, PilC1 and PilC2, are capable of mediating adhesion independently.

However, PML can also recruit BAX and p27KIP1 to PML-NBs and can mediate apoptosis independently of caspase 3 activation [ 39].