Sentence examples for mediated inactivation of from inspiring English sources

Specifically, we have shown that siRNA mediated inactivation of MBNL1, which binds to the stem of the CUG hairpin, results in increased dispersion of nuclear foci in DM1 cells [46].

DCA mediated inactivation of PDK1 kinase activity requires DCA to be bound with the N-terminal helix bundle of PDK.

It was also possible that CTBT mediated inactivation of Sod1p and/or Sod2p might contribute partly to the observed ROS formation.

Our findings indicated that thapsigargin induced oxidative stress and neuronal apoptosis in cultured neurons is at least partly mediated inactivation of Pink1.

In summary, our study indicates that thapsigargin induced oxidative stress and neuronal apoptosis in cultured neurons is at least partly mediated inactivation of Pink1.

For instance, the methylation mediated inactivation of the CDH13 gene occurred in 33% of breast cancers and 35.5% of tested established tumor cell lines [ 39].

Coupienne et al. [162] suggest that ROS induce the AKT-mediated inactivation of NF-κB, an inhibitor of apoptosis.

RA-mediated inactivation of NF-κB could be blocked by the diphenyleneiodonium chloride (DPI; a ROS inhibitor).

Through concomitant Cre-mediated inactivation of E-cadherin and PTEN in mammary epithelium, we generated a mouse model of classical ILC (CLC), the main histological ILC subtype.

Cre-recombinase-mediated inactivation of Hdac3 led to a delay in cell-cycle progression, cell-cycle-dependent DNA damage, and apoptosis in mouse embryonic fibroblasts (MEFs).

Moreover, this hypermethylation-mediated inactivation of HoxA4 and HoxA5 was associated with a poor prognosis in other myeloid and lymphoid malignancies and might be a biomarker of more severe disease (Strathdee et al., 2007).