Per AIG, its last material weakness was re mediated in the fourth quarter of 2008.] Yet none of AIG's officers were held accountable for Sarbanes-Oxley violations after making materially misleading public statements and signing off on false SEC filings.
A third reviewer mediated in the event of disagreement.
The possible scenario of molecular events in cervical cancer suggested by our study portrays the evasion of apoptosis mediated in two ways, first, the sequestration of the pro-apoptotic protein BAD by 14-3-3ζ 14-3-3ζ 14-3-3ζverexpression of the anti-apoptotic protein Bcl-2 managed by the interaction of c-Myc and E2F1 [ 60].
Interactions were observed with both Rap2A and Rap2B, and this binding appeared to be mediated by the first RBD in the tandem array; however, in contrast to the interaction with H-Ras (Figure 1A), the interaction was independent of the nucleotide state of Rap2A/2B (Figure 1B and 1C).
The essential role of BRDT in spermatogenesis is mediated by the first bromodomain (BRDT(1); Figure 1A), which binds the tetra-acetylated amino-terminal tail of histone 4 (H4Kac4) with moderate potency (20 μM) (Morinière et al., 2009).
There is general consensus that the organic cation transporter (OCT1) plays a major role in mediating the first step in metformin cellular response [ 51– 51].
If reviewers disagreed, agreement was sought by consensus after consulting the Cochrane tool guidance [20], with a third reviewer mediating in the event of on-going disagreement.
If there was disagreement between the reviewers, agreement was sought by consensus after consulting the protocol, with a third reviewer mediating in the event of on-going disagreement.
The binding of vinculin to VASP is mediated by the first proline-rich region in the vinculin neck domain (Brindle et al., 1996).
While exposed extracellular matrix proteins play an essential role in mediating the first steps of platelet recruitment in damaged vessels, fibrinogen plays a predominant role in platelet aggregate formation.
