Sentence examples for mediated in several from inspiring English sources

A PLC-dependent signal might be mediated in several ways.

Disassembly is thought to be mediated in several ways, including by changes in tension and posttranslational modifications or by proteolytic cleavage of critical adhesion components (16– 16).

Thus, any "supportive" effect of IDO-specific T cells on other immune cells may well be mediated in several direct and indirect manners.

Its contributions to transcriptional regulation are mediated in several different ways: although PARP-1 can act as a promoter-specific co-regulator and by binding to specific enhancer sequences and insulators, its predominant function in transcription can probably be attributed to a modulatory influence on chromatin structure.

Essentially, this can be achieved by one of two mechanisms: either by the action of proteins that can bend these membranes into tubules, in a manner that is possibly similar to that of amphiphysin, endophilin, sorting nexins and others (Antonny 2006), or via the alteration of the lipid composition of these trans-Golgi membranes, which can be mediated, in turn, by several processes.

Since cytochrome c release plays a major role in mediating apoptosis in several experimental systems [ 36- 38], we determined whether U0126-induced apoptosin in HepG2 cells was associated with cytochrome c release in the cytoplasm.

The infiltrated macrophages produce numerous proinflammatory cytokines, such as TNF-α [ 38], which has been shown to mediate inflammation in several models of renal injury, including tubulointerstitial injury [ 39].

This suggests that the heterogeneity of the effects of trauma could in part be mediated by several environmental risk factors, including pre-, peri-, and post-traumatic stressful life events [ 3- 5].

Taken together, these findings suggest sex-specific involvement of Y2 receptors on NPY-expressing neurons in the regulation of energy metabolism, particularly adiposity, which could be mediated by changes in several key enzymes involved in lipolysis and lipogenesis in liver and skeletal muscle.

Resistance to EMB in Mycobacterium tuberculosis isolates is mediated by mutations in several genes involved in arabinan synthesis notably three emb (arabinosyl transferase) and iniA (isoniazid-inducible) genes.

Finally, ecosystems provide us with medical and genetic resources, which are necessary to prevent or cure diseases [ 41]. Figure 3 shows that the impact of globalisation on each proximal health determinant is mediated by changes in several distal factors.