Sentence examples for mediated in large from inspiring English sources

The caspase-mediated apoptosis induction by PGG was mediated in large part by activation of p53 as established through siRNA (small interference RNA) knockdown and dominant negative mutant approaches [ 7].

The interaction between these receptors and G proteins is mediated in large part by the third intracellular loop of the receptor.

The interactions between the infective organisms and their hosts are mediated in large part by secreted proteins, known collectively as the "secretome".

In conclusion, our results demonstrate the cardioprotective effect of HBOC on I/R heart and reveal that this protection was mediated in large part by attenuation of mitochondrial oxidative damage.

HSV-1 attachment, followed by fusion and entry, is mediated in large part by the binding of viral surface glycoproteins to cell surface receptors, primarily through heparan sulfate (HS) glycosaminoglycan residues.

Our results demonstrate the cardioprotective effect of PolyPHb on cold I/R-injured hearts and revealed that this protection was mediated in large part by attenuation of TLR2 and -4/NF-κB signanding pathway and could possibly down-regulate the inflammatory response.

2, 3 Regulation of the pivotal point of mitochondrial outer membrane permeabilization is mediated in a large part by the B cell chronic lymphocytic leukemia/lymphoma 2 (BCL-2) protein family.

Other recent studies suggest that with both SOD1 and TDP-43, the aggregates may mediate injury in large part via interactions with mitochondria.

The anti-inflammatory capabilities of HA are mediated, at least in large part, by its antioxidant activity [ 101- 108].

These differences in mRNA abundance are thought to be mediated post-transcriptionally, in large part by differential stability resulting from interactions with RNA binding proteins [ 13, 25].

Studies in the model species Arabidopsis thaliana and rice indicate that these adjustments are mediated by large changes in the transcriptome.