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Together these observations suggest that some polycomb repressed sites rely more specifically on KDM2B mediated RING1B occupancy for normal H2AK119ub1 and polycomb mediated gene repression (Endoh et al., 2012).
Evidence for a direct role for DNA methylation in NRSF/REST mediated gene suppression has also been reported [ 50] and a connection between REST binding and polycomb mediated gene repression has been established [ 51].
Cordeiro, T. N. et al. A single residue mutation in Hha preserving structure and binding to H-NS results in loss of H-NS mediated gene repression properties.
SRF mediated gene repression is not clear, but it might involve the recruitment by SRF of transcriptional silencers [23], [24].
PcG mediated gene repression requires a complex series of events, initiated by the recruitment of PRC2 to target genes resulting in the tri-methylation of histone H3K27, which then preserves silencing of the transcriptional program through consecutive cell divisions [13].
AML1-ETO mediated gene repression is believed to occur through an epigenetic mechanism involving H3K27me3 [ 12].
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Casciello, F. et al. G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis.
Mukaida, N. et al. Novel mechanism of glucocorticoid-mediated gene repression.
Mechanisms by which interferon (IFN -γ actIFN -γ genes to promote mactivates activation are well studied, but little is known about mechanisms and functions of IFN-γ-mediated genesrepression.
This strongly suggests that HDAC-mediated gene repression is involved in the transcriptional function of NKX2.2 in Ewing's sarcoma.
The interaction with ING1 and ING2 was shown to enhance the Alien-mediated gene repression [ 38].
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