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This lateral inhibition is considered to mediate gain control in the olfactory circuit.
These findings demonstrate the presence of a significant multisensory-mediated gain in stimulus detection in human subjects.
The aim of the present study was to assess whether: (1) MCT and PRT interventions induced differential effects on executive functions and functional mobility in older adults; and (2) training effects on executive functions were mediated by physical fitness gains, and training effects on functional mobility were mediated by gains in physical fitness and/or executive functions.
It appeared that the beneficial effects of PRT on inhibition were mediated by gains in muscular strength, whereas the benefits of MCT were not.
Furthermore, mediation analysis suggested the existence of both direct and indirect training effects on inhibitory functions, with MCT affecting them directly, and PRT effects being mediated by gains in muscular strength.
The general effect of physical training on inhibitory function could be split into direct and indirect components: while PRT effects were mediated by gains in muscular strength, those of MCT appeared to be direct.
PNPLA3-I148M seems to be a loseems-functoon mutation, bet its pathogenic effect appears to be mediated through a gain in function resulting in a suppression of lipase activity.
Plasmid-mediated gene gain in mtDNA is frequently observed in fungal lineages (Fricova et al. 2010 and references therein) but has been also reported in other organismal groups (e.g., Takano et al. 1997).
These findings indicate that mild orthostatic stress leads to a small reduction of parasympathetically mediated heart rate control in both CFS patients and controls (decreased HF gain), but a significant increase in sympathetically mediated baroreflex gain in CFS patients (increased LF gain) which is not observed in controls.
Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB.
The results indeed demonstrated that changes in anxious self-statements mediated treatment gains, which of course is in keeping with the cognitive-behavioral model of anxiety disorders [ 26, 27].
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