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The differential effects of SC-560 on the temperature response may in fact be mediated further upstream in the process (i.e. centrally in the brain).
The results demonstrate LPA-stimulated migration in oral carcinoma cells through LPAR3, mediated further by PKC, which acts either in concert with or independently of EGFR transactivation.
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TNFR1 also mediates further reductions in proliferation and elevated cell death following exposure to recombinant TNFα.
Initial interactions occur between the biomaterial surface, water, ionic species and organic molecules, which then mediate further interactions with body tissues.
In many non-immune cells, ASC-speck release is accompanied by cell death10, but in immune cells, including microglia, ASC-speck release is often better tolerated and can propagate inflammation — perhaps because ASC specks are taken up by neighbouring microglia to mediate further interleukin release.
After antigens, containing numerous epitopes, are recognized by the human immunological system, B lymphocytes will synthesize and secrete miscellaneous antibodies targeting different epitopes to mediate further immunological process.
On 18 January 1978, China attempted to mediate further negotiations between Kampuchea and Vietnam when Vice Premier Deng Yingchao travelled to Phnom Penh, where she was met with strong resistance by Kampuchean leaders.
The induction of these genes is dependent upon serum response factor (SRF) and mediates further changes in gene expression, including regulation of sarcomeric and hypertrophic genes [15], [16].
Furthermore, several acetyltransferases have bromodomains, which could mediate further cooperativity between acetylation sites.
PDK1 phosphorylated at the Ser residue (an active form of PDK1) translocates to the cytosolic fraction to mediate further signalling pathways.
When bound to the DNA, these proteins often mediate further physical interactions that provide an additional scaffold besides the regulatory sequence.
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