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These preliminary results suggest the possibility of a new, "softer" pharmacological approach to ADHD: hydrophobic mode matched peptide allosteric augmentation of the activity of indigenous dopamine with respect to D2DAR mediated function, in place of stimulant drug-induced presynaptic dopamine release or impairment of dopamine uptake.
Sphingosine and sphingosine-1-phosphate regulate the immune cells and exert receptor mediated function in cells [23, 24, 41].
Extracellular Hsp90 protein (eHsp90) potentiates cancer cell motility and invasion through a poorly understood mechanism involving ligand mediated function with its cognate receptor LRP1.
Our previous results [15] demonstrated that the adhesion-blocking antibody ASC-8, had no effect on anchorage-independent growth of tumor cells, but a non-adhesion blocking antibody, ASC-3, did inhibit this β4 mediated function.
This result suggests continued functional importance for these regions in all four species, yet in spite of this sensitivity, no candidate regions were identified for possible L1 mediated function.
The two BNT scores measure the verbally mediated function with the greatest precision.
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Fossati-Jimack, L. et al. Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells.
Adachi, O. et al. Targeted disruption of the MyD88 gene results in loss of IL-1 and IL-18-mediated function.
Furthermore in the aged, increased cyclooxygenase (COX -2-mediated PGE2 produCOX -2-mediatedes to deCOX -2-mediated-mediated function.
Hsp90-mediated function of NLR receptors in plant and animal innate immunity depends on the cochaperone Sgt1 and, at least in plants, on a cysteine- and histidine-rich domains (CHORD -containing protein Rar1.
Taking together, the present results show that dominant negative GSK-3 transgenic mice show reduced DA D2-R-mediated function in striatum and further support a link between dopaminergic neurotransmission and GSK-3 activity.
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