Sentence examples for mediated fragmentation of from inspiring English sources

Having obtained promising detection results from only 5 cycles product, the feasibility of target sequence detection in extracted genomic DNA without PCR amplification, but with the vortex mediated fragmentation of the large genomic DNA into small pieces was examined.

Enzymatic fiber fragmentation was more apparent when the reaction was agitated, consequently enhancing the mechanically mediated fragmentation of the fibers.

To determine whether or not MPA could effect this transformation more widely we investigated the MPA mediated fragmentation of a recombinant 21 kDa protein sample, His10-WT human erythropoietin (EPO).

Caspase-3-mediated fragmentation of caspase-9 occurs at Asp330 and results in a 37-kDa fragment, the most abundant fragment in the P31res1.2 cells.

However, caspase-3-mediated fragmentation of caspase-8 is reported to result in 41 and 43 kDa fragments, such as those found in this study.

Blocking TGF-β by administration of a neutralizing antibody accentuated the LCWE-mediated fragmentation of elastin and induced an overall loss of medial elastin without increasing the inflammatory response.

Although the role of the oxaziridine in this process is not known,[ 50] the formation of 65 in all cases is consistent with a presumably facile base-mediated fragmentation of the target diene 68, generated in situ (Scheme  8).

The impact of caspase cleavage was confirmed in a cell based model, showing that predominantly caspase-1-mediated fragmentation of expanded ataxin-3 resulted in increased aggregation and treatment with caspase inhibitors prevented inclusion formation in vitro [ 61].

In this manuscript, we focused the assessment of this possibility on factors that are known to be required for Hsp104-mediated fragmentation of Sup35 amyloid in vivo (Ssa1 and Sis1).

The release of proapoptotic factors, such as cytochrome c (with consequent formation of the apoptosome and caspase activation), from depolarized mitochondria into the cytosol is a significant event in the induction of apoptosis and is associated with Drp1-mediated fragmentation of the mitochondrial network.

To further define the structural prerequisite for SOCS6-mediated fragmentation, we ectopically expressed a series of SOCS6 mutants in AD293 cells.