This study demonstrated that baculovirus conferred efficient gene delivery and mediated expression of growth factors (TGF-β1, IGF-1 and BMP-2) to therapeutic levels in rabbit chondrocytes.
In contrast, inducible nitric oxide synthase- (NOS2) mediated expression of NO promotes endothelial dysfunction and atherogenesis.
Small interfering RNA-mediated reduction of p53 expression resulted in a specific decrease in GSTP1 expression and in tumor cells with mutated p53; adenovirally mediated expression of wild-type p53 increased GSTP1 expression significantly.
These results demonstrate HSV1 mediated expression of ChR2 can be used to generate spiking activity.
We have documented that adenovirus mediated expression of constitutively active AKT or MEK increases survival [5], [40].
Similar to results with MMP-9 expression, inhibitors of PI3K or Notch1 activation, LY294002 (PI3K) or GSI-I abrogated PIM2 mediated expression of CD44 (Figure 7).
IL-32β sensitizes/amplifies inflammatory cytokine mediated expression of cell adhesion molecules, as well as the expression of those same cytokines.
These results suggest that serum mediated expression of CYLD via SRF is dependent on the activation of p38MAPK, which can in turn reduce proliferation of MEFs.
Similar reports of c-di-GMP mediated expression of virulence genes and survival in host have been published for Salmonella typhimurium and Pseudomonas aeruginosa [21], [22].
Lentiviral vector mediated expression of Bcl-xL in PC12 cells allowed cells to survive in the absence of serum or NGF [36].
The second construct used for the production of transgenic animals mediated expression of EGFP-F under the control of the Thy1 promoter (Fig. 1A).
