This more favorable safety and tolerability profile is likely mediated by decreased exposure of ocular tissues to bimatoprost when applied dermally.
Unlike the HDX assays, however, hydroxyl radical-mediated modification probes exposure of amino acid side chains rather than backbone amide hydrogens.
Consistent with the involvement of an src-family protein kinase in P2X7-mediated p38 activation, exposure of astrocytes to BzATP in the presence of either PP2, genistein as well as SB203580 failed to induce pore opening, as assayed by YO-PRO-1 uptake.
Finally, we demonstrated that decreased numbers of pDCs in the blood of HIV-infected individuals may be due in part to HIV-mediated cell death, as exposure of pDCs to a cell line expressing HIV induced substantial levels of apoptosis and necrosis, which was diminished by treatment with a drug that inhibits fusion of HIV with its target cell.
These data confirm that mutSOD1-mediated toxicity proceeds through exposure of the toxic BH3 domain.
The 5xERE GFP line serves as a tissue-specific reporter of ER-mediated transcriptional activity following exposure of zebrafish embryos to estrogenic compounds.
Skin tests, the third line of evidence, remain the gold standard for the detection of IgE-mediated reactions, and involve exposure of the mast cells of the skin of patients who experience anaphylaxis to the suspected allergen [ 13].
The mapping to a Pak2 independent activity of the PxxP motif is reminiscent of the Nef mediated reduction of cell surface exposure of MHC-I and chemokine receptor molecules [28], [39], [40], [41], [42], [43].
Similar to the marked inhibition of TLR9-mediated induction of IFN-α, exposure of pDCs with cell culture-derived HCV resulted in a more than 80% inhibition of CpG-A-induced TNF-α production (Figure 5B).
It is an immune-mediated phenomenon due to the exposure of heparin.
