Jadhav, R. R. et al. Genome-wide DNA methylation analysis reveals estrogen-mediated epigenetic repression of metallothionein-1 gene cluster in breast cancer.
Using a systems approach, we uncovered a unique and fundamental role for Mtf2 in erythrocyte differentiation, which occurs in part through PRC2-mediated epigenetic repression of canonical Wnt signaling.
In some experimental models, oncogene-induced transformation has been shown to be dependent on BMI-1-mediated epigenetic repression of the p16/ARF-encoding CDKN2A [44], [44].
Certainly, it will be interesting to determine the mechanisms by which ATRA reduces the expression of EZH2 and abrogates EZH2-mediated epigenetic repression.
Additional file 1: Genome-wide DNA methylation analysis reveals estrogen-mediated epigenetic repression of Metallothionein-1 gene cluster in breast cancer.
In a recent report, BRCA1-mediated epigenetic repression at the promoter region of miRNA-155 was identified as a novel mechanism by which BRCA1 carries out its tumor suppressor functions.
The RAD51 gene has a well established role in DNA repair through homologous recombination and, accordingly, EZH2-mediated epigenetic repression of RAD51 associates with accumulation of DNA damage and chromosome abnormalities.
The most important insight from Chang and colleagues [ 8] is the observation that genomic instability induced by EZH2-mediated epigenetic repression of DNA repair, that is, RAD51, results in expansion of the BTIC population.
Arabidopsis COOLAIR (cold induced long antisense intragenic RNA) and COLDAIR (COLD ASSISTED INTRONIC NONCODING RNA) play significant roles in cold response and are required for the vernalization-mediated epigenetic repression of FLC [ 44, 55].
Clearly, this analysis will involve experimentally validating the targets of miRNA-155, and determining whether there are other genes regulated by this same mechanism - that is, BRCA1-mediated epigenetic repression.
In a recent report, EZH2-mediated epigenetic repression of DNA damage repair in breast tumor initiating cells (BTICs) was identified as a mechanism that could promote expansion of BTICs, and may contribute to cancer progression.
