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There is some evidence suggesting that deprenyl has cytoprotective and antiapoptotic properties [19], [20], [21], effects that are possibly mediated either through an adaptive increase in superoxide dismutase activity [22], [23] or increased cell-cell adhesion [24].
In Drosophila melanogaster, yellow has been implicated in melanin pattern formation on larval mouth parts and adult wings, mediated either through insertion of a transposable element closely downstream of yellow [32] or by a wing-specific cis-regulatory element [10].
This process can be mediated either through receptor-ligand interactions or through internalization by recipient cells via endocytosis.
This role might be mediated either through an indirect influence on the host immune response or through a more direct influence on the epithelial tumor cell.
This interaction may be mediated either through direct binding to TERT or the RNA subunit of telomerase [34,41] (D. Shippen, personal communication).
This is proposed to occur though dimerization, which could be mediated either through homotypic interactions between the BIR1 domains [ 32] or heterotypic interactions involving both the BIR domains and the C-terminal portion of MALT1 [ 33].
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This pathway involves the regulation of the activation state of cofilin through phosphorylation mediated either by PI3K-RHO-CDC42-PAK-LIMK or PLC-LIMK [25].
Copper manipulations were mediated either by increased copper entry, through over-expression of the plasma membrane transporter Ctr1A, or by misregulation of cytoplasmic copper trafficking through loss-of-function mutations of the Atox1 and FKBP52 genes.
These interactions appear mediated either by DNA-protein interactions, or through RNA-protein interactions that can be altered during changes in gene expression programs.
More evidence is being gathered for a gain-of-function toxicity mediated either by RNA foci formed from the expanded intron or through repeat associated non-ATG translation.
Hence, this phenotype is mediated either cell autonomously by daf-16 in the intestine or through daf-16-to-other signaling.
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