Sentence examples for mediated efflux of from inspiring English sources
The MDCK-MDR1 in vitro model uses an immortalized mammalian cell line that stably expresses the transfected human MDR1 gene product (P-glycoprotein (P-gp)) to assess the potential for P-gp mediated efflux of compounds.
We hypothesized that P-gp mediated efflux of doxorubicin, a known substrate of P-gp, was being blocked by lovastatin via an unknown mechanism.
Various excipients which are commonly used in the pharmaceutical formulations are reported to be potent inhibitors of Pgp mediated efflux of drugs.
Side population cells were demonstrated as those with low fluorescence in both the blue and red channels, which was ameliorated in cells pre-incubated with verapamil or fumitremorgin C, which block multi-drug resistance protein (mdr) or mdr-like mediated efflux of the Hoechst dye 26.
Although this has typically been interpreted as evidence for exchange, it must be borne in mind that a facilitated transporter can also display trans-stimulation (i.e., faster return of the carrier because of the mediated efflux of intravesicular substrate, leading to accelerated uptake by speeding up the transport cycle; Fig. 1 B ).
The aim of our study was to provide a microelectrode method for measuring the multidrug transporter mediated efflux of doxorubicin as well as a corresponding data analysis method for quantifying the efflux kinetic parameters.
A relationship between ABCG2 and ROS has also been previously reported: Scoparo et al. reported that hispidulin increased ROS production and inhibited the ABCG2-mediated efflux of mitoxantrone28.
Likewise, they demonstrated concentration-dependent inhibition of BCRP-mediated efflux of BODIPY-prazosin with a potency similar to that of Ko143.
Similarly, patients affected by GLUT2 mutation do not reabsorb glucose and various filtered solutes because of impairment in GLUT2-mediated efflux of glucose [42].
MDMA binds to and reverses the dopamine transporter (DAT) and the serotonin transporter (SERT) to produce carrier-mediated efflux of DA and 5-HT, respectively [9].
As a membrane transporter, ABCA1 facilitates the formation of HDL via apolipoprotein AI (apoAI -mediated efflux of cholesterol apoAI -mediatedds from many tissuefflux, [8], [9].
