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An example of moderation of a mediated effect is a case in which a mediation process differs for different age groups (i.e., children vs. adolescents).
While the coefficients are all at least marginally significant in the individual models (see Text S1), the mediated effect is not.
This CCL20 mediated effect is likely to occur via attracting Treg-cells to the tumor mass or directly stimulating CRC cancer cells or both.
One downside of a causal approach to establishing a mediated effect is the requirement for the relationship between the focal predictor and the outcome to be significant.
According to this approach, a mediated effect is achieved if zero lies outside the upper and lower limits of a 95% bootstrapped CI for the estimate of the indirect effect.
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This suggested that the calcium-phosphate mediated effect was independent of CAR.
The standard error of the mediated effect was computed using the multivariate delta method [ 27].
However, at that dose no ERα- mediated effect was seen on uterus weight.
The CIs around this "mediated effect" were derived from bootstrapping (with 5,000 generated datasets), as previously described in detail (19).
MDA or TAS was added to the fully adjusted regression models, and the "mediated effect" was quantified by the absolute attenuation of the regression coefficient.
A new probabilistic domain switching function considering the surface ferromagnetic anisotropy and the interface charge-mediated effect is proposed.
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