Sentence examples for mediated dysfunction of from inspiring English sources

The mutation mediated dysfunction of PI3K may alter the regulation of Bcl-2.

The mechanism of reduced testosterone in men with OSA is likely to occur through OSA mediated dysfunction of the pituitary-gonadal axis.

This phenomenon is thought to represent a consequence of inflammation-mediated dysfunction of the blood-brain barrier (BBB), thus allowing neurotoxic mediators to extravasate from the peripheral circulation into the subarachnoid space or into the brain parenchyma.

It has also been reported that epigenetic-mediated dysfunction of the BMP receptor-IB (BMPR-IB) inhibits differentiation of glioblastoma-initiating cells [28], but the role of hypoxia in BMP pathway regulation has not been previously considered in other studies.

To further determine the mechanism(s) involved in heroin use- or heroin use plus HCV infection-mediated dysfunction of CD56+ T cells, we examined whether heroin use or heroin use plus HCV infection was associated with the induction of intracellular suppressors of IL-12 signaling pathway.

One suggested mechanism for a nonimmune-mediated dysfunction of muscle fibres is the so-called 'endoplasmic reticulum (ER) stress response'.

Nevertheless, epigenetic-mediated dysfunction of BMP receptor 1B in a subset of GBM tumours represses the pro-differentiative effects of BMPs, clearly indicating that tumour cells can hamper anti-cancer treatments to varying degrees.

To exclude the involvement of those NO independent factors in calpain-mediated dysfunction of endothelium-dependent relaxation, we demonstrated that deletion of eNOS abrogated the beneficial effect of calpastatin over-expression on endothelium-dependent relaxation in diabetic aortic rings.

Tavener et al. reported that the primary role of TLR4 mediated cardiac dysfunction can be attributed to the immune system [ 29], while other reports have shown that TLR4 mediated dysfunction is due to cardiac expression of the protein [ 30– 30].

Previous studies have suggested that high amounts of NO derived from iNOS activity are cytotoxic and implicated in the autoimmune-mediated dysfunction and destruction of islet β-cells during development of type 1 diabetes [25].

17, 18 The striking parallels between patient symptoms and the consequences of NMDAR hypofunction described above underscore the importance of determining the mechanisms of antibody-mediated dysfunction in this disease.