Sentence examples for mediated destabilization of from inspiring English sources
Thank you for submitting your work entitled "Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase" for peer review at eLife.
In this scenario, the C5A-mediated destabilization of the membrane would have a more dramatic effect on a viral than a cell membrane.
We cannot exclude the possibility that rare examples of Microprocessor-mediated destabilization of mRNAs may be found in specific cellular contexts or at levels too low to be identified using current deep sequencing technology.
Among these enzymes, a reasonable candidate might be Dicer1, involved in dsRNA-mediated destabilization of retrotransposon transcripts [47]-[49] [47]-[49]andto generation and survival of crucial-cerebral neurons [54].
This suggested an inhibitory role for iASPP in the BRMS1-mediated destabilization of p300 and CBP.
CHIP-mediated destabilization of the BACE1 at post-translational level led us to investigate the mechanism through which CHIP exerts its effect upon BACE1 protein.
For example, the TRAMP-mediated destabilization of RNAs produced from heterochromatic regions in fission yeast appears to be sequence-independent [ 92].
A suggested reason for TRIAD1 being ubiquitinated by MDM2 is to control p53 apoptosis signalling through balancing TRIAD1-dependent activation of p53 and MDM2-mediated destabilization of p53 [ 84].
Thus, the present study has identified a mechanism in which activation of cGMP/PKG2 by inhibition of PDE5 results in GSK3 β-mediated destabilization of β-cat and consequent suppression of canonical Wnt signaling.
However, it was not reported whether kinase inhibitors also change LRRK2 protein levels and future experiments should elucidate the precise molecular mechanism responsible for kinase inhibitor-mediated destabilization of the full-length WT and mutant protein.
As the three discrete pathways activated by Tax are inhibited by 17-DMAG treatment, the simplest interpretation suggests that all these effects arise from 17-DMAG-mediated destabilization of the Tax protein itself.
