Sentence examples for mediated deregulation of from inspiring English sources

We propose the adaptive deregulation of the epigenome in response to stress (ADERS) hypothesis, which considers epigenetically mediated deregulation of transcription under accumulated stress as a means by which cells attempt to restore homeostasis.

In agreement with earlier observations using rapamycin to block mTORC1 activity (7, 8) (Figs  1– 3), downregulation of endogenous mTORC1 activity via raptor-specific siRNAs mediated deregulation of cell cycle progression (from 56.2% to 83.3% G0/G1 cells and from 35.4% to 12.6% S phase cells) (Fig.  4 B; P < 0.05) and of size of cells in all cell cycle phases (Fig.  4C and D; P < 0.05).

HDAC inhibitor-mediated deregulation of chaperone function, in turn, deregulates protein homeostasis and induces protein misfolding and proteotoxic stress.

ScFvs with different binding specificity could be employed either independently, to discriminate the different functions of E7 thus gaining an insight into the mechanism of E7-mediated deregulation of cell proliferation, or in combination, to enhance their anti-E7 activity.

Along with other factors, aberrant AGO2 expression was observed to be associated with multiple defects in trophoblast differentiation through deregulation of miRNAs mediated mechanisms.

The E2Fs are key regulators of cell proliferation and death [25], [26], and common deregulation of E2F-mediated transcriptional programs is a hallmark of cancer transcriptomes [27].

Thus, our data reinforces the idea that the eCB-system is a critical component of PFC physiology and that deregulation of eCB-mediated synaptic plasticity may participate to the etiology of PFC-related pathologies.

Deregulation of exosome-mediated transport leads to disease development.

Deregulation of NR-mediated transcription accounts for the deleterious effects of many EDCs.

Melanoma cells ensure their dependence on E2F1 through the deregulation of pRb-mediated negative regulation of E2F1.

Elevated pERK levels were observed in the hippocampus of RSK2 knockout mice, resulting in deregulation of ERK-mediated gene transcription (Mehmood et al., 2011; Schneider et al., 2011).