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This result positively indicates that the CPR mediated depletion of peroxide involves diffusible radicals.
We next analyzed the functional effects of siRNA mediated depletion of ARTN in BT549-TWIST1 cells.
However, in cells with forced expression of TWIST1, siRNA mediated depletion of ARTN exerted no effect.
Signs of anaemia can be associated with chronic inflammatory conditions due to a cytokine mediated depletion of erythropoin [ 51].
Based on these findings, we tested whether siRNA mediated depletion of BRD4 in U87MG cells significantly reduced proliferation.
Clearly, the siRNA mediated depletion of PU.1 and the consequent loss of LIMD1 expression (Fig. 5) supports this possibility.
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Similarly, shRNA-mediated depletion of p27 inhibited rapamycin-induced autophagy.
Systemic, enzyme-mediated depletion of L-arg has been investigated in mouse models and human trials.
siRNA-mediated depletion of cyclin D1, but not cyclin D3, reduces MCF-7 cell proliferation.
In addition, CAPE attenuated the CCl4-mediated depletion of antioxidant enzyme (catalase, superoxide dismutase and glutathione-S-transferase) activities.
RNAi-mediated depletion of TbUNC119 showed no apparent phenotype.
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