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These findings are well in line with our results where the ANP effect in EDS cells was fully mediated by a PDE-II mediated decrease of cAMP levels.

Relatively to PL mediated decrease of Akt effectors phosphorylation levels, PL affected cellular proliferation, dose-dependently.

To ascertain, whether cisplatin mediated decrease of PTEN protein is due to ubiquitin-proteasome pathway, we used MG132, a proteasome inhibitor during present study.

These data are consistent with our hypothesis that Klotho mediated decrease of endogenous oxidative stress down regulates the p38 MAPK activity by attenuating the upstream MKK3/6 kinases.

These findings indicate that RU 38486 acts through an inhibition of the corticosterone- mediated decrease of protein- synthesis without affecting other factors that act predominantly on the level of protein degradation.

However, estrogen-mediated decreases of Aβ, even in its more toxic forms, do not correlate consistently with improved cognition.

In contrast, control lenti-shRNA did not prevent Poly-G3-mediated decreases of cAMP levels in tumor cells.

However, in this study, we found ouabain-mediated decreases of p-Src (Y416) and Na+/K+-ATPase subunits in A549 cells after 1-day incubation.

This CES2-mediated decrease of liver TG accumulation coincided with decreased liver lipogenic gene expression and increased fatty acid oxidation.

In contrast, the Fe-mediated decrease of lateral root (LR) length and density is enhanced in fer1-3-4 planto due to a defect in LR emergence.

The inhibition was caused by gp2-mediated decrease of the RNAP binding affinity to template and non-template strand segments of the transcription bubble downstream of the − 10 promoter element.

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