Sentence examples for mediated death of from inspiring English sources

In this way they are more close to hierarchy model of BH3-only proteins activation involving mitochondrial mediated death of HCSF following the stimulus by ceramide [6].

These protein interactions along with the generation of ROS and JNK signaling appeared to be the key events in the cells response to ceramide and may help in defining the mechanism of ceramide mediated death of HCSF in the present paradigm.

Possibly, the H2O2 detected in the nucellar layers exceeded the detoxifying capacity of ROS detoxifying enzymes, including CAT, thus triggering PCD, the mechanism also proposed by He and Kermode [ 81] for ROS mediated death of white spruce megagametophyte.

In addition, the neurotoxic effects of FasL in the brain had been previously described in a model of chronic idiopathic demyelinating polyneuropathy, where macrophage-mediated demyelination was shown to be dependent upon FasL mediated death of Schwann cells [56].

A second model of TRAIL-mediated death of uninfected cells has been proposed.

In this study, we demonstrated that celastrol inhibited LeTx-mediated death of the murine macrophage cell line RAW264.7.

Based on these studies, we have hypothesized that inhibition of reactive gliosis reduces protease levels in the retina and prevents protease-mediated death of RGCs.

In this investigation, we have used two glial toxins to inhibit reactive gliosis and have evaluated their effect on protease-mediated death of RGCs.

As shown in Fig. 3C and as previously reported by Alvira et al. (2007), treatment with resveratrol at doses of up to 30 µM did not prevent LK-mediated death of neurons.

Since our previous studies indicated that reactive astrocytes play a major role in protease-mediated death of RGCs, we hypothesized that inhibition of reactive gliosis down-regulates the expression of detrimental proteases and prevents RGC loss.

A number of observations suggest that CD4 T cell depletion in HIV is not only related to direct, virus-mediated death of infected cells but also to cell death of a large number of uninfected bystander T cells in the setting of increased activation that follows infection with HIV.