To demonstrate the relevance of Ndk-mediated deactivation of Rab5 and Rab7 to the virulence of mycobacteria, we knocked-down Ndk gene expression in BCG using established antisense strategy [49], [50].
Thus, KIAA1524/CIP2A may be essential in defining the kinetics of the subsequent PP2A-mediated deactivation of the MTORC1 substrates.
Insulin-mediated deactivation of lipolysis is associated with transcriptional downregulation of ATGL and HSL expression (Kershaw et al., 2006; Kralisch et al., 2005).
HIF-1α stabilization by hypoxia-mediated PHD and FIH inactivation can also proceed through ROS-mediated deactivation of PHDs and FIH in a manner that is not necessarily dependent on intracellular oxygen tension [ 309– 309].
In gastrin-mediated signaling deactivation of RHOA and RAC1 is effectuated by GAPs, ARHGAP4 and RGS2, respectively.
In addition, AKT-mediated phosphorylation and deactivation of the transcription factor FOXO results in its nuclear export and proteasomal degradation, thus releasing cells from FOXO-mediated cell cycle arrest.
In light of this observation, we hypothesized that one mechanism of IFN-γ mediated sensitization to apoptosis was deactivation of anti-apoptotic Stat3, possibly as a consequence of increased transcriptional activation and expression of Stat1.
The four GO terms were phototransduction (8 genes; GO 0007602), deactivation of rhodopsin mediated signaling (5 genes; GO 0016059), regulation of cell development (11 genes; GO 0060284), and behavior (17 genes; GO 0007610).
A deficiency of all 3 BCAA may impair milk protein yield through deactivation of mTORC1-mediated upregulation of eIF2Bε and eIF2α abundances.
We found that the slow deactivation of α3β2γ2-mediated currents is associated with a relatively small rate and extent of apparent desensitization.
A PI3K-dependent signal transition of Rho-family GTPase activities occurs during FcR-mediated phagocytosis and PI3K-dependent deactivation of Cdc42 at the signal transition is necessary for phagocytosis.
