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We propose that the above approaches warrant further exploration as potential approaches for alleviating complement mediated damage to ocular tissues in AMD.
This disease is frequently caused by complex hepatocellular metabolic dysfunctions due to the impaired insulin action, leading to disordered metabolism of fat and free fatty acids and subsequent oxidant mediated damage to the hepatocytes [6].
This interpretation is based on the assumption that complete knockout of mitochondrial SOD must be associated with a dramatic increase in oxidative damage, in particular to mitochondria, and that the lack of lifespan effects therefore indicates that ROS mediated damage to mitochondria does not determine the rate of ageing in C. elegans.
It is thought to be released through mechanical or inflammatory mediated damage to the membranes or placenta before birth [ 10].
Light mediated damage to the lens proteins can only occur due to the presence of light absorbing chromospheres.
Ethyl gallate was found to be effective at 100 μg/mL concentration by inhibiting the free radical mediated damage to BSA and pBR322 DNA.
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The extract also significantly and dose-dependently protected against Fe-NTA plus H2O2-mediated damage to lipids and DNA.
Immune-mediated damage to glomerular structures is largely responsible for the pathology associated with the majority of glomerular diseases.
Efficacy of morin was evaluated against oxidative stress-mediated damage to primary hepatocytes by tert-butyl hydroperoxide (tBHP) and acetaminophen.
In immunocompromised hosts and young children, uncontrolled growth of the bacilli leads to the disease development, whereas in immunocompetent adults, immune system-mediated damage to lung tissue is to blame for the TB pathology.
In part, the persistence of these factors is due to early HIV-mediated damage to the gastrointestinal tract in which microbial cell wall components are released into the circulation [66].
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