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Therefore, we assumed that the expression of CEACAM6 might be of importance for the induction of proliferation by overcoming the CEACAM1-4L mediated contact inhibition.
In the crystal structure a single residue, Asp533, is observed to have a direct interaction with the oxydril oxygen on topotecan ring E. In the simulation such an interaction is substituted by a water mediated contact, present for 84% of simulation time (see Figure 4 for a representative snapshot of the topotecan binding pocket in the simulation).
Posterior turning and migration of the salivary gland is dependent on integrin mediated contact between the gland and surrounding tissues.
In addition, the DN mediated contact between them and the patient on her own initiative, and alerted the FP when unexpected problems appeared, e.g., if a patient's health deteriorated or if a patient did not take the medicine.
This phase formed over the surface of the Pd-BnM and is likely to act as an insulating layer, limiting surface mediated contact between the Cr VI) or electron donor and the reactive Pd-BnM surface.
Down-regulation of cortactin by RNA interference, revealed an essential role for cortactin in dendritic spine morphogenesis [ 57] and in E-cadherin mediated contact formation in epithelial cells [ 58].
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Similarly, we compared the water mediated contacts in the protein-protein interfaces of protein∶protein and protein∶protein∶DNA complexes.
The average number of water mediated contacts between the protein-DNA interfaces of protein∶protein∶DNA complexes is ∼11.82±1.3 (Table S8).
It has been discussed that water content and water mediated contacts in the protein-DNA interface are important components of protein-DNA interactions [34], [35].
The water mediated contacts in interfaces of components in protein∶protein∶DNA complexes play less important role (found in less quantity) in the stability and specificity of recognition then in interfaces of components in the binary protein∶protein and protein∶DNA complexes.
These results suggest that water mediated contacts in interfaces of components in protein∶protein∶DNA complexes play less important role in the stability and specificity of recognition then in interfaces of components in the binary protein∶protein and protein∶DNA complexes.
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