We report here that the mTORC1-mediated consequences on cell cycle and cell size are separable and do not involve effects on mTORC2 activity.
Making use of non-transformed, non-immortalized primary human fibroblasts we found that (i) the mTORC1-mediated consequences on cell cycle and cell size are separable and do not involve effects on mTORC2 activity; (ii) In addition, we report here for the first time that mTORC2 is a potent regulator of mammalian cell size and cell cycle via a mechanism involving Akt/TSC2/Rheb.
Lastly, since it was possible that the losartan-mediated effect on reduction of inflammation was not a direct effect, but a consequence of reduced fibrotic remodeling in C7-hypomorphic dermis, we analyzed the effect of short-term losartan treatment.
Here, we studied the clinical consequences of BST-2 expression in breast tumors, the functional role of BST-2 in mammary tumorigenesis, and the cellular basis for BST-2-mediated effect on mammary tumorigenesis.
More specifically, escape routes of transgenes (i.e. pollen- versus seed-mediated gene flow), dispersal abilities (i.e. cattle-mediated seed movements) and consequences on the fitness of admixed individuals should be systematically investigated (see also Willenborg and Van Acker 2008).
Such upregulation on human target cells for meningococci and the consequences on bacterial pilus-mediated interactions are not known.
In the present study, we were interested to analyze the effects of HSF1 activation (Hsp90 inhibitor NVP-AUY922) and inhibition (NZ28, HSF1 knockdown) in different human cancer cells on the NK cell ligands MICA/B and its consequences on NK cell-mediated lysis.
To date, no study has investigated the broader consequences on gene expression of siRNA-mediated knockdown of EPHB4 in prostate cancer.
Steroid-mediated maternal effects in viviparous organisms may also have long-lasting consequences on life-history aspects of the offspring and be an important evolutionary factor [ 62].
Our results suggest a possible role for MOP1-mediated pathways in regulation of higher-order chromatin organization that results in direct and indirect consequences on gene expression in maize.
The growth phenotypes of E. coli strains harboring mutant alleles of RRF and initiation factor 3 (IF3) genes and their consequences on λimmP22 phage replication upon AGA-minigene expression reveal that IF3 facilitates the RRF-mediated processing of the stalled ribosomes.
