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Ryan, M. D. & Drew, J. Foot-and-mouth disease virus 2A oligopeptide mediated cleavage of an artificial polyprotein.
DAPT inhibits γ-secretase mediated cleavage of APP in a dose dependent manner (Fig. 1A).
Using this system we demonstrate that pharmacological agents that induce ER stress consistently decrease γ-secretase mediated cleavage of APP.
Calpain mediated cleavage of filamin A can be reduced by phosphorylation of the protein at serine.
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The RIP3-KD-mediated cleavage of p65/RelA was at least partially mediated by caspases, notably caspase-6.
Caspase-mediated cleavage of syntaxin 5 and giantin accompanies inhibition of secretory traffic during apoptosis.
Yousefi, S. et al. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.
Apoptotic cell death is executed by the caspase-mediated cleavage of various vital proteins.
In contrast, inhibition of AEP-mediated cleavage of α-synuclein (wild type and A53T mutant) diminishes α-synuclein's pathologic effects.
Plk1-mediated degradation of Cep68 and separase-mediated cleavage of pericentrin release both pools of Cep215, thereby promoting centriole disengagement.
Wirawan, E. et al. Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria.
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