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Valosin-containing protein (VCP) can facilitate degradation of misfolded proteins but its accumulation in aggresome-bodies on CS exposure [6] impairs both autophagy and proteostasis mediated clearance of misfolded proteins.
The results of this study provide a rationale for an alternative antiviral strategy, which can be explored to overcome IFN-α resistance, and to enhance the immune mediated clearance of virus HCV infected cells.
Indeed, in studies performed in mice [10] and non-human primates [11], [12], the development of rtTA antibodies and cytotoxic T cell mediated clearance of rtTA expressing cells was observed.
IgM antibodies are important for complement mediated clearance of apoptotic cells [107].
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Fab binds to antigens and can be responsible for target-mediated clearance of a mAb.
Our findings highlight that TFEB is a central regulator in lysosome-mediated clearance of toxic protein aggregates.
Data show that both resident and BM-derived cells contribute to type I IFN-mediated clearance of lytic virus within the TG.
Variation in the efficiency of neutrophil-mediated clearance of B. burgdorferi may underlie differences in the severity of Lyme arthritis observed in the patient population and suggests avenues for development of adjunctive therapy designed to augment host immunity.
We propose that a failure of macrophage-mediated clearance of fibrin may be the cause of RCM formation after collagen-based hydrogel implants and that mesenchymal stem cell therapy promotes clearance of fibrin and prevents RCM formation.
These data indicate that a co-inoculation with B. bronchiseptica results in rapid antibody-mediated clearance of B. parapertussis.
Our results indicate that flagellar function plays an important role against SP-A-mediated clearance of P. aeruginosa.
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