Sentence examples for mediated clearance from inspiring English sources
Recently high throughput cross-interaction assays were developed to screen mAbs for off-target mediated clearance.
In addition, the fusion partner replaces Fab and may be responsible for target mediated clearance.
High CYP mediated clearance as well as glucuronidation were targeted to achieve high intrinsic clearance coupled with multiple routes of clearance to minimise drug-drug interactions.
IgM antibodies are important for complement mediated clearance of apoptotic cells [107].
MTRX1011A exhibited non-linear PK properties in the dose ranges tested, as was expected for an antibody with high target mediated clearance (CL).
Prior Phase I studies have demonstrated that the clearance of sarilumab is biphasic, consistent with target mediated clearance that is revealed at low drug concentrations.
Fab binds to antigens and can be responsible for target-mediated clearance of a mAb.
Our findings highlight that TFEB is a central regulator in lysosome-mediated clearance of toxic protein aggregates.
Data show that both resident and BM-derived cells contribute to type I IFN-mediated clearance of lytic virus within the TG.
These authors went on to show that Prn allows B. bronchiseptica to resist neutrophil-mediated clearance.
These data indicate that a co-inoculation with B. bronchiseptica results in rapid antibody-mediated clearance of B. parapertussis.
