However, Chung et al. showed that the surface charge of mesoporous silica particles could mediate cellular uptake rate or even cellular uptake route of the particles [29].
We prepared sterically stabilized liposomes with encapsulated recombinant human TG1 (rhTG1) and equipped with a highly cationic lipopeptide vector to mediate cellular uptake.
LRP, which belongs to a gene family involved in mediating cellular uptake of cholesterol-rich lipoproteins (the low-density lipoprotein receptor (LDLR) gene family), is highly expressed in atherosclerotic lesions [20], [21] and has been shown to represent a susceptibility gene for atherosclerosis [13].
ABCD2 and ABCD4 both involved in the transport of fatty acids, and SLCO1A2, which mediates cellular uptake of organic ions such as bile acids and steroidal compounds, appeared to have the greatest degree of positive selection as indicated by the low H values in all four populations (Table 4).
The xc− cystine/glutamate antiporter is a plasma membrane transporter mediating cellular uptake of cystine in exchange for intracellular glutamate with a stoichiometry of 1 : 1 (Lo et al, 2008).
In general, the efficiency of a CPP in mediating cellular uptake is a function of its total electric charge and amino acid sequence insofar as these properties determine its 3-D structures and potential interactions with membranes molecules [ 8– 10].
20 Moreover, it has been reported that both pancreatic α- and β-cells express a vesicular GABA transporter, which transports GABA into the intracellular vesicles for packaging before it is released, and GAT3, which mediates cellular uptake of GABA.
The hCtr1 expression level may be related to the aggressiveness or prognosis of the prostate cancer and to the response of prostate cancer to cisplatin chemotherapy because hCtr1 was recently reported to be able to mediate cellular uptake of cisplatin [ 62].
ApoB siRNAs conjugated to cholesterol and other fatty acids such as stearoyl or docosanyl conjugates mediated cellular siRNA uptake and gene silencing in vivo (Wolfrum et al, 2007).
Transferrin receptor mediates cellular uptake of iron, and the expression on cells reflects iron needs and erythropoietic activity.
