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Therefore, effector proteins such as AES and/or LRP6-ICD which are capable of modulating TCF/LEF-1 activity through long Groucho/TLE and/or β-catenin, have the potential to influence Wnt pathway mediated cellular functions such as proliferation/differentiation.
These observations are consistent with the results from the individual networks involved in activation of T cells, and IFN-γ mediated cellular functions.
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Myosin II motor proteins are believed to be involved in mediating cellular functions by undergoing filament assembly in the cells.
Phosphorylated VEGFRs are considered to mediate cellular functions by activating various types of signaling pathways.
Neurofibromin exhibits Ras GTPase activating protein (Ras-GAP) activity that is thought to mediate cellular functions relevant to disease phenotypes.
In addition to signaling by the NO molecule alone, ROS including superoxide, hydrogen peroxide, and peroxynitrite are also involved in mediating cellular functions.
The inositol ring can be phosphorylated at the D3, D4 or D5 position to produce a set of seven distinct phosphorylated derivatives, which are preferentially located in various cellular membranes or microdomains, specifying their identity, and mediating cellular functions by recruiting various effector proteins with specialized lipid-binding domains [ 1].
Integrins directly associate with uPAR to mediate cellular function (Wei et al, 1999).
The study proved that multilayer-film-coated Ti substrates positively mediated cellular biological function in vitro and improved bone healing in vivo.
This critical involvement of DOCK8 in immune cell functions could in turn determine the role of septin 7 in the immune system, considering the fact that septins act as potential scaffolding platforms for interacting proteins, which mediate cellular functions.
OPN, a secreted phosphoprotein, exists both as an immobilized ECM molecule in mineralized tissues and as a cytokine that mediates cellular functions involved in inflammation and ECM remodelling [31].
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