Sentence examples for mediated cell motility from inspiring English sources

Although, we have demonstrated a role for PI3K in EC motility [47], blocking PI3K with LY294002 had no effect on S1P-induced PLD activation [12] indicating PLD- and PI3K-dependent pathways of S1P mediated cell motility.

Having established that blocking SphK1 decreases intracellular S1P levels and attenuates cell migration, next we investigated the role of sphingosine-1-phosphate lyase (S1PL), a pyridoxal phosphate dependent enzyme, in S1Pext mediated cell motility and wound healing.

Further, Hall and Turley (1995) proposed that tyrosine kinase pp60c-src is associated with RHAMM in cells and is required for RHAMM mediated cell motility.

In another NPC cell line, CNE1, DNP also mediated cell motility and invasion followed by enhanced phosphorylation of LYRIC at serine 568.

Boyden chamber invasion assay indicated that DNP mediated cell motility and invasion of NPC cell 6-10B in vitro, and experiments with nude mice indicated that DNP increased 6-10B metastasin in vivo.

RHAMM was originally described in the context of one of these functions, which is to facilitate HA mediated cell motility [ 48, 61– 64] but was more recently shown to affect centrosomal function and mitotic spindle integrity.

Earlier reports have also suggested that uPAR interacts with integrin complexes to promote the interaction of FAK with p130Cas [73] and p130Cas CrkII signaling complex to activate Rac, thereby resulting in a Rac-mediated cell motility and invasion [74].

On the other hand, activation of MMPs is also involved in CCL3-mediated cell motility [ 36].

IGF-1 is known to influence cell adhesion to the substratum and integrin-mediated cell motility [ 52].

EGF-mediated cell motility and invasion was also reduced, effects mediated via α6 β4 integrin (Deng et al, 2012).

Lastly, CXCL12-mediated cell motility was CXCR7-dependent, with CXCR7 expression required for optimal expression of CXCR4 protein.