Sentence examples for mediated cell lysis from inspiring English sources

Inhibition of the classical complement pathway could be a natural mechanism to avoid a precipitated antibody mediated cell lysis, whereas Hexb may have uncharacterized immune properties modulating neuronal functions.

Moreover, treatment of Bcl-2 transgenic mice [21], where B cells were only slightly reduced, further corroborates the hypothesis of a BAFF mediated survival on the one hand and makes complement mediated cell lysis improbable on the other hand.

DRS binds complement factors but does not inhibit complement mediated cell lysis [ 56, 57], whereas SIC inhibits complement mediated cell lysis [ 58].

In the defence against pathogens, haemostasis is as fundamentally important as innate immunity and complement- mediated cell lysis.

It has been shown to be located in the cytosol and nucleolus, functioning as an inhibitor of TNF mediated cell lysis.

Rituximab is known to deplete B cells by antibody-dependent, cell-mediated cytotoxicity, by complement mediated cell lysis and/or by apoptosis [ 41].

133 Alemtuzumab (Campath®), a humanized monoclonal antibody against CD52 surface antigen expressed on most malignant T cells, has been shown to mediate antibody-dependent cellular cytotoxicity, 134, 135 complement-mediated cell lysis, 136 and apoptosis.

Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-mediated cell lysis due to deficiency of GPI-anchored complement regulators.

In summary, all three effector cell systems differentially express FcγRIIIA and provide dose-dependent ADCC pathway activity, yet only primary NK and engineered NK-92 cells are capable of inducing ADCC-mediated cell lysis.

For example, HSV-1 glycoprotein gC prevents complement-mediated cell lysis and virus neutralization [10], [11].

Inhibition of VLY-mediated cell lysis in these tissues may therefore, have important physiologic relevance.