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The capacity of M-T7 to block early chemokine mediated cell invasion was further assessed after injection via systemic (i.v).v
Studies have shown that Pyk2 mediated cell invasion [ 23], and we have observed the activation of Pyk2 by BDNF.
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Seeing that ADAMTS-12 regulates the expression and function of αvβ3 integrin, and that αvβ3 has been previously shown to promote an invasive phenotype in human EVTs, we next tested whether ADAMTS-12-mediated cell invasion is facilitated by αvβ3.
In addition, it has been shown previously that Ser5 phosphorylation is required for L-plastin-mediated cell invasion [8], [9].
Phosphorylation of L-plastin on residue Ser5 increases its F-actin binding activity and is required for L-plastin-mediated cell invasion.
Our findings demonstrating that ADAMTS-12 could modulate JEG-3 cell-ECM adhesion in an RGD dependent manner suggested that ADAMTS-12-mediated cell invasion could also be regulated through a similar RGD/integrin-dependent mechanism.
Cells pre-treated with triptolide (a MKP-1 inhibitor), reversed rosiglitazone-mediated cell invasion and migration.
We have shown that LPA-mediated cell invasion involves increased NET1 expression and RhoA activation.
The extent to which MMP-2 contributes to FAK-mediated cell invasion in other cancer cells remains unknown.
Our genetic epistasis analysis demonstrated that Src42A modulates JNK signaling-mediated cell invasion, cell death and thorax closure upstream of Bendless (Ben) and dUev1a.
Here we report, for the first time in cancer cells, direct evidence that MMP-2 is an important player of FAK-mediated cell invasion in HNSCC-derived cells.
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