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These results suggest that compounds A and B selectively interfere with aromatase in breast cancer cells, but not estrogen receptor (ER) downstream to disrupt androgen mediated cell growth.
The anti-cancer effects of these compounds were determined by their ability to inhibit IGF-1 mediated cell growth of MCF-7 breast cancer cells.
Structural modification of one of the two catechol rings of NDGA was found to have little effect upon the inhibitory potency against both kinase activity of the IGF-1R and IGF-1 mediated cell growth of MCF-7 cells.
The results presented in this report indicate that VDRFF may facilitate the antiproliferative effects on estrogen mediated cell growth in part by down-regulating ERα expression as it was significantly reduced in these cells compared to the other two cell lines after 1,25D3 treatment.
These results indicated that ER β mediated cell proliferation and GPR30 mediated cell growth inhibition.
Adjuvant ADT to EBRT has its synergistic effects by decreased tumor cell hypoxia, decreased DNA repair, and decreased AR mediated cell growth [ 11].
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These results showed that enzymatic ILK mediated the formation of the IQGAP1 Ras complex to trigger ERK1/2- and NF-κB-mediated cell growth.
Jensen, D.E. et al. BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression.
As with mutations within the AR polyproline domain, knockdown of SH3YL1 attenuated androgen-mediated cell growth and migration.
12. Chung BH, Mitchell SH, Zhang JS, et al: Effects of docosahexaenoic acid and eicosapentaenoic acid on androgen-mediated cell growth and gene expression in LNCaP prostate cancer cells.
The Lkb1/AMPK system has been proposed to act as an energy sensor to low ATP levels inhibiting mTOR-mediated cell growth [9].
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