Similarly, sRNA-mediated cell fate decision has also been extensively investigated [4], [5].
The specific pro-apoptotic regulation is also confirmed by changes in gene expression, which include a clear induction of pro-apoptotic genes involved in p53-mediated cell fate decision, such as TSP1, maspin, PMAIP1 NOXA), and GADD45a.
Our online cell biosensor measurements reveal for the first time the time scale of metabolic response until onset of cell death under cisplatin treatment, which is in good agreement with models of p53-mediated cell fate decision.
This finding implies the importance of cofactors in p53-mediated cell fate decisions.
This dichotomy of p53-mediated cell fate decisions reflects the Janus-like pleiotropy of ROS biology.
In addition, ncRNA-mediated cell fate switching appears to be more efficient.
Despite its importance, mechanistic insight into the nuclear responses that underlie auxin-mediated cell fate reprogramming is lacking.
Importantly, p53-mediated cell fate decisions also prevent cancer cells to be killed by chemotherapeutic drugs, thus leading to poor clinical outcomes.
It is imperative to understand the mechanism of p53-mediated cell fate decisions for the efficient clinical application of drugs activating p53 [ 42].
Therefore, Hzf acts both as a p53 target and as an important regulator in p53-mediated cell fate determination during cortical neurogenesis (see Figure 7).
Furthermore, the data implies that c-FOS might be replaced in the AP-1 complex by another AP-1 member, thereby altering a function of AP-1 [ 30] to facilitate response to HRG-mediated cell fate.
