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While some researchers argue that the amyloid deposits are a mere downstream reflection of the neurodegeneration mediated by yet unidentified pathological events, others believe that Aβ is responsible for the neurodegeneration, and hence the plaques are central to the disease.

In fact, we have identified several non-catalytic activities of heparanase (i.e., cell adhesion, gene transcription, signal transduction) [9], [51], [57] thought to be mediated by yet unidentified cell surface receptors [57].

Thus, some cardiovascular effects of PM might be mediated by yet unexplained mechanisms.

Such mechanisms could be mediated by yet unidentified circulating factors, including those not measured with the current targeted metabolomics approach (Fig 6H).

It was previously reported that GABARAP binds to microfilaments (actin) as well as microtubules (β-tubulin); the actin binding is not direct, and it may be mediated by yet unknown proteins (Wang and Olsen, 2000).

Thirdly, the effects of alcohol on HSF activity are mediated by yet another unusual mechanism the formation of specific HSF1 HSF2 heterotrimers whose biochemical properties are distinct from those previously characterized for other types of stress (Sarge et al, 1993; Sistonen et al, 1994; Loison et al, 2006; Östling et al, 2007; Sandqvist et al, 2009).

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Almost all bacterial pathogenesis is mediated by adhesins, yet when elaborated by normal flora, they might also be important for the exclusion of pathogens.

In the case of cadherin engagement, this is mediated by a yet not identified src kinase family member [35], in case of FX06, this depends on Fyn.

The effect therefore seems to be mediated by a yet unidentified cannabinoid-binding site.

Nevertheless, the interaction might be indirect and mediated by a yet unknown protein that interacts with members of both complexes.

3) Putative indirect c-Myc actions, mediated by transcription factors regulated by overexpression of c-Myc on the protein level or mediated by as yet unknown mechanisms.

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