The UPR are mediated by three ER membrane-bound mediators including inositol-requiring enzyme-1 (IRE-1), PKR-like endoplasmic reticulum kinase (PERK), and activating transcription factor 6 (ATF6), which are bound by the abundant ER chaperones glucose-regulated protein 78 (GRP78) in unstressed conditions.
The agreement was reached following hours of talks mediated by three EU foreign ministers.
Illustrated in this figure is a hydrogen-bonding network, mediated by three conserved bound water molecules within the groove.
Figure 1 The response of the brain to systemic infection is physiologically triggered by an activating signal that is mediated by three pathways.
Ukraine's president says he has reached a deal with the opposition to end the crisis, after all-night talks mediated by three EU foreign ministers.
The central excitatory neurotransmitter effects of (5 -glutamic acid [(5 -glutamic mediacid by three heterogeneous classes of ionotropic receptors: N-methyl-D-aspartic acid (NMDA), 2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA), and kainic acid (KA) receptors, and a number of subtypes of metabotropic receptors.
For M. tuberculosis, its dormancy within a macrophage could potentially be mediated by three pairs of relBE-like genes that are expressed during infection [21].
Conversely, RanBP1 stabilizes the HEAT-9 loop in its inward conformation through interactions mediated by three basic residues located in RanBP1 strand 1 and in the β3β4 loop.
The UPR is a complex pathway that is mediated by three distinct signaling tracks initiated by the sensors inositol-requiring enzyme 1 (IRE-1), activating transcription factor 6 (and6) and PKR-like ER kinase (PERK) [9].
In Vibrio spp. QS is mediated by three types of synergistically acting signalling molecules: acyl-homoserine lactones (AHL), cholera-autoinducer-1 (CAI-1) and a mixture of interconvertible molecules collectively called autoinducer-2 (AI-2) [1]–[4].
The biological effects of galanin are mediated by three G protein coupled receptors, GalR1, GalR2 and GalR3, that show a widespread distribution throughout the central and peripheral nervous system and may participate in different aspects of the galanin function [11].
