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Transmembrane movement of S-nitroso- l-cysteine is mediated by system L amino acid transporters (56).
Therefore, overstimulation of neuronal excitatory amino receptors via enhancement of the extracellular glutamate concentration cannot account for the excitotoxic insult mediated by system xc− under aglycemic conditions.
These observations confirm bidirectional flux of alanine across the plasma membrane, resulting in equilibration of intracellular and extracellular alanine concentrations, with alanine uptake mediated by System A transport.
These results show clearly that the resistant cells acquire the cystine transport activity mediated by system xc−, which does not occur in the sensitive cells.
As shown in Table 1, 50 nM SNAT1-specific siRNA did not affect the Na+-independent component of C-MeAIB uptake (i.e. that not mediated by system A).
In endothelial cells, l-arginine transport is mediated by system y+, reflecting activity of the cationic amino acid (CAT) transporters and system y+L, which reflects heterotrimeric amino acid transporter activity [14].
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Only DMI, a noncompetitive inhibitor of T3 transport mediated by MCT8, MCT10 (33), and an inhibitor of Trp transport mediated by system-L (44), could, on its own, significantly inhibit [I]L-T4 uptake by 29% compared with no inhibitor controls (n = 9, P < 0.001), a similar degree to excess T4.
Uptake studies have indicated that CPE expresses system N, while the transport activity for small neutral AA (mediated by systems A and ASC) was absent [ 116], which confirms finding by Preston and Segal [ 115] that uptake of A and ASC substrates by isolated perfused CP was very low.
Thus, progesterone modulation of ovulation most likely is mediated by a system other than the kinin system.
The pro-tumorigenic activity mediated by immune system cells and associated inflammatory mediators, is countered by antitumor immunity [ 20, 21].
It is thus highly likely that any feedback effects among these six systems are mediated by other systems that have not been assessed.
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